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SRIWIJAYA JOURNAL OF MEDICINE
Published by Universitas Sriwijaya
ISSN : -     EISSN : 26223589     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Sriwijaya Journal of Medicine (SJM) is a scientific journal managed by Faculty of Medicine Universitas Sriwijaya, Indonesia. It publishes original research articles and reviews in Biomedical Sciences, Medicine (Neurology, Cardiovascular, Respiratory, Gastrointestinal, Urogenital, Endocrine and Metabolism, Integument, Mental Health, Obstetry and Gynecology, Ophtalmology, ENT, Musculosceletal) and Public Health Medicine. Sriwijaya Journal of Medicine (SMJ) published three times a year (January, April, October).
Arjuna Subject : Kedokteran - Anatomi
Articles 5 Documents
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Search results for , issue "Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023" : 5 Documents clear
The Role of Mtor Inhibitors in Endocrine Resistance Therapy of Breast Cancer Type ER+ Syarinta Adenina; Bantari Wisynu Kusuma Wardhani
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.146

Abstract

Breast cancer is the leading cause of death in women. Although hormonal therapy has produced positive results in HR+ breast cancer, resistance to this therapy remains a challenge in the treatment of breast cancer. Various mechanisms have been proposed as an explanation of resistance in breast cancer, one of which is the activation of the PI3K/AKT/mTOR pathway. The PI3K/AKT/mTOR pathway is a transduction pathway that regulates many important aspects in both normal cells and cancer cells, including cell proliferation, apoptosis, cell morphology and migration, protein synthesis, and integrase metabolism. Preclinical dan clinical data show inhibition of this pathway can improve survival, especially in resistant hormonal therapy models. The use of mTOR inhibitors (everolismus) has been approved by the FDA as a combination therapy with exemestane for postmenopausal women with HR+/HER2-breast cancer.
Antibiotic Susceptibility of Staphylococcus sp. in Diabetic Ulcer Patients at Dr. Mohammad Hoesin General Hospital, Palembang Imaulina Sri Chelsee; Rizki Andini Nawawi; Masayu Farah Diba
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.153

Abstract

The high prevalence of diabetic ulcers and the resistance of Staphylococcus sp. to antibiotics can complicate the treatment of diabetic ulcer patients with Staphylococcus sp. This study aimed to determine the pattern of susceptibility of Staphylococcus sp. in patients with diabetic ulcer at Dr. Mohammad Hoesin General Hospital Palembang in January 2019-August 2022. This research was an observational descriptive study using total sampling conducted in September-November 2022 at Dr. Mohammad Hoesin General Hospital Palembang. Data was obtained from patient medical records and laboratory results of patients with diabetic ulcer disease infected with Staphylococcus sp. from January 2019 to August 2022. Prevalence of Staphylococcus sp. infection in diabetic ulcer patients was low (15 of 77 diabetic ulcer patients, 19.5%). There were 19 bacterial isolates from 15 diabetic ulcer patients. A total of 8 coagulase-negative Staphylococcus sp. (CoNS) and 11 coagulase-positive Staphylococcus sp. (CoPS) isolates were tested for their susceptibility to antibiotics. Both CoPS and CoNS bacteria in diabetic ulcer patients were most susceptible to linezolid (90.9% for CoPS and 100% for CoNS) and most resistant to benzylpenicillin (81.8% for CoPS and 87.5% for CoNS).
GLUT4 as A Protein Target for Type 2-Diabetes Mellitus Therapy With Natural Compounds Vivi Hendra Sutandar; Mgs. Irsan Saleh; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.154

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.  Medication for Type 2-Diabetes Mellitus (T2DM) mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking; thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
Association Between Social Support and Postpartum Depression : A Systematic Review Leo Medianto Faziqin; Iche Andriany Liberty
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.173

Abstract

Postpartum depression (PPD) is one of the most common mental disorders occurring during the postpartum period among women. Prevalence of postpartum depression is estimated to be about 10–15% worldwide. Many risk factors are supposed to play a role leading a new mother to maternal postpartum depression which can considerably affect the baby, mother, family and also the society. Some study shown that social support has been effective in helping women cope with PDD and lack of social support increase the risk of PPD. This study aimed to know the association between social support and postpartum depression. This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) standard. The search using 6 databases SAGE Journals, Pubmed, Science Direct, Springer, Wiley Online Library, and Oxford University Press. The search strategy in each of the databases used keywords such as: (((social support) OR (family support)) AND ((postpartum depression) OR (postnatal depression)) AND (cross sectional)). The process of searching and selecting the studies which yielded a total of 1.814 articles. Only six studies were suitable to answer the study question. Each of the studies were conducted in different areas comprising Iran, China, India, and Korea. The outcome of this study shown that there was association between social support and postpartum depression. Woman with poor social support increase the risk of postpartum depression.
Rhizophora apiculata Bark Ethanolic Extracts Prevent Kidney Damage Caused by Cigarette Smoke in Male Rats Syazili Mustofa; Sarasmita Nirmala Dewi
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.204

Abstract

Rhizophora apiculata mangrove bark contains high levels of antioxidants, including triterpenoids, steroids, saponins, and tannins. The high antioxidant content can prevent oxidative stress, one of which is caused by free radicals from cigarette smoke. This research aimed to determine the potential of Rhizophora apiculata mangrove bark to protect against damage to the kidney organs of male white rats (Rattus novergicus) of the Sprague-Dawley strain exposed to cigarette smoke. This study used 25 mice divided into 5 groups for 30 days, namely group K(-), which was not given exposure to cigarette smoke and mangrove bark extract; group K(+), which was only given exposure to cigarette smoke; group P1, which was given the extract mangrove bark with a dose of 26.27 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day, group P2 which was given mangrove bark extract with a dose of 56.55 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day, and group P3 which was given mangrove oil bark extract at a dose of 113.1 mg/kg BW and given exposure to cigarette smoke 24 cigarettes per day. On day 31, the rats were euthanized, and their kidneys were prepared for histology. Kidney histology was observed, and kidney damage was assessed from the histology of glomerular and renal tubular damage. The kidney damage score is 0 if there was no damage, 1 if inflammatory cell infiltration was found, 2 if Bowman space edema or swelling of tubular epithelial cells was found, 3 if necrosis was found. Then, take the average of each renal tubular and glomerular damage score and add them together for a total damage score, namely 0-6. The median kidney damage score in the K (-) group was 0.4, the K (+) group was 3.6, the P1 group was 2.4, the P2 group was 2.4, and the P3 group was 2.2. The results of the Kruskal-Wallis test obtained a p-value of 0.001, meaning there were significant differences in at least the two treatment groups. This research showed that administering Rhizophora apiculata mangrove bark extract could prevent histological damage to the kidneys of male white rats of the Sprague-Dawley strain caused by cigarette smoke.

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